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Weight reduction is essential for improving health outcomes in people with obesity and type 2 diabetes. We assessed the efficacy and safety of tirzepatide, a glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, versus placebo, for weight management in people living with obesity and type 2 diabetes. Published April 28, 2022 Updated May 1, 2022 An experimental drug has enabled people with obesity or who are overweight to lose about 22. 5 percent of their body weight, about 52 pounds on average,. Tirzepatide was associated with an increased incidence of gastrointestinal adverse events: nausea was the most frequent event with all Tirzepatide doses, especially 15 mg (OR 5. 60, 95% CI 3. 06); Tirzepatide 15 mg was associated with higher incidences of vomiting (OR 5. 50, 95% CI 2. 59) and diarrhea (OR 3. 31, 95% CI 1. Original Article Aug 05, 2021. Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. Weight Management Tirzepatide vs. Semaglutide: How Do These Medications Compare for Weight Loss? Tirzepatide and semaglutide are type 2 diabetes drugs often used for weight management. Mounjaro (Tirzepatide) is the first dual GIP/GLP-1 receptor agonist which means it works on the glucose-dependent insulinotropic polypeptide (GIP) receptors and the glucagon-like peptide-1 (GLP-1) receptors. Mounjaro can be used as a single therapy or with other diabetes medicines including metformin, sulfonylureas or SGLT2 inhibitors
Tirzepatide was administered as a once-per-week subcutaneous injection (5 mg, 10 mg, or 15 mg) with a prefilled syringe. 5 mg once per week, and increased by 2·5 mg every 4 weeks until the randomised dose was achieved and maintained for the study duration (appendix p 23). Background As the disease progresses, many patients with type 2 diabetes have difficulty in reaching treatment goals. We aimed to assess the efficacy and safety of tirzepatide, a novel GIP and GLP-1 receptor agonist, compared with dulaglutide in Japanese patients with type 2 diabetes. 6, 2022 /PRNewswire/ — Eli and Company (NYSE: LLY) announced today that the U. Food and Drug Administration (FDA) has granted Fast Track designation for the investigation of tirzepatide for the treatment of adults with obesity, or overweight with weight-related comorbidities. Similarly, a significantly greater percentage of patients receiving tirzepatide vs placebo achieved the 2 composite outcomes, HbA 1c less than 7. 0% (78%-80% vs 12%) or less than or equal to 6. Tirzepatide is administered subcutaneously once weekly because of its half-life of 5 days. In the phase 1 and phase 2 trials tirzepatide demonstrated dose-dependent reduction in HbA1c (up to 2. 4%) and body weight (up to 11. 3 kg) in patients with T2DM. The clinical efficacy of tirzepatide is superior to the GLP-1 RA dulaglutide. Tirzepatide was associated with an increased incidence of gastrointestinal adverse events: nausea was the most frequent event with all Tirzepatide doses, especially 15 mg (OR 5. 60, 95% CI 3. 06); Tirzepatide 15 mg was associated with higher incidences of vomiting (OR 5. 50, 95% CI 2. 59) and diarrhea (OR 3. 31, 95% CI 1 ibericosentumesa.com/archivos/8979/2023/
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