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OBJECTIVE: To test the hypothesis that stimulation of muscle with beta-2 agonists reduces disease manifestations in patients, we investigated efficacy and tolerability of clenbuterol in Spinal and bulbar muscular atrophy (SBMA). BACKGROUND: SBMA is an adult-onset, X-linked, lower motor neuron disease, characterized by slowly progressive muscle weakness and atrophy. Objective: To test the efficacy and tolerability of clenbuterol in patients with spinal and bulbar muscular atrophy (SBMA). Methods: Twenty patients with a diagnosis of SBMA were given oral clenbuterol (0. 04 mg/d) for 12 months. The primary efficacy end point was the change from baseline of the walking distance covered in 6 minutes at 12 months. Clenbuterol-sensitive delayed outward potassium currents in a cell model of spinal and bulbar muscular atrophy Pflugers Arch. Online ahead of print. Authors Vladimir A Martínez-Rojas 1 , Daniele Arosio 2 , Maria Pennuto 3 4 5 , Carlo Musio 6 Affiliations. To test the efficacy and tolerability of clenbuterol in patients with spinal and bulbar muscular atrophy (SBMA). Methods: The primary efficacy end point was the change from baseline of the walking distance covered in 6 minutes at 12 months
Clenbuterol-sensitive delayed outward potassium currents in a cell model of spinal and bulbar muscular atrophy Pflugers Arch. Online ahead of print. Authors Vladimir A Martínez-Rojas 1 , Daniele Arosio 2 , Maria Pennuto 3 4 5 , Carlo Musio 6 Affiliations. OBJECTIVE: To test the hypothesis that stimulation of muscle with beta-2 agonists reduces disease manifestations in patients, we investigated efficacy and tolerability of clenbuterol in Spinal and bulbar muscular atrophy (SBMA). BACKGROUND: SBMA is an adult-onset, X-linked, lower motor neuron disease, characterized by slowly progressive muscle weakness and atrophy. Objective: To test the efficacy and tolerability of clenbuterol in patients with spinal and bulbar muscular atrophy (SBMA). Methods: Twenty patients with a diagnosis of SBMA were given oral clenbuterol (0. 04 mg/d) for 12 months. The primary efficacy end point was the change from baseline of the walking distance covered in 6 minutes at 12 months. To test the efficacy and tolerability of clenbuterol in patients with spinal and bulbar muscular atrophy (SBMA). Methods: The primary efficacy end point was the change from baseline of the walking distance covered in 6 minutes at 12 months 200 mcg to cc clenbuterol
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